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Creatine
Updated 3/18/2026
8.3Rating
Muscle
Performance
Cognitive
Longevity
Energy
Bone
Metabolism
Prevention
Inflammation
Diabetes
Research Summary
Creatine is a naturally occurring nitrogenous organic acid composed of three amino acids: arginine, glycine, and methionine. While the body synthesizes it primarily in the liver and kidneys, about 95% is stored in skeletal muscle as phosphocreatine, with the remainder found in the brain and other tissues. It is one of the most extensively researched and validated supplements in the world, traditionally used by athletes but increasingly recognized for its benefits in healthy aging, cognitive performance, and women's health.
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