Fisetin

Fisetin is a naturally occurring bioactive flavonol and polyphenol found in various fruits and vegetables, most notably in strawberries, apples, persimmons, and onions. In recent years, it has emerged as one of the most promising 'senolytic' compounds—substances that help the body identify and clear out aged, non-functioning cells. While it is chemically related to other flavonoids like quercetin, research highlights fisetin as having superior potency in targeting cellular senescence and systemic inflammation.