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Nattokinase

Updated 3/11/2026
7.0Rating
Cardiovascular
Longevity
Metabolism
Prevention
Inflammation
Metabolism

Research Summary

Nattokinase is a potent proteolytic enzyme extracted and purified from natto, a traditional Japanese food made from fermented soybeans. It is a serine protease produced by the bacterium Bacillus subtilis var. natto during the fermentation process. Unlike most soy foods, nattokinase is specifically valued for its unique enzymatic activity rather than its nutritional content. It has been a cornerstone of cardiovascular research in Japan since its discovery in 1980 by Dr. Hiroyuki Sumi, and it is increasingly recognized globally for its role in supporting vascular health and longevity.

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